Dexter Dodge Ball is an old game from cartoonnetwork.com where you play as Dee Dee to dress Dexter up like a doll.
Since this game is 16-bit and Microsoft was too lazy to allow non real-mode 16-bit applications to work on 64-bit Windows it is not compatible with any 64-bit version of Windows.
A workaround using software called
WineVDM (OTVDM) can be used to run this game on 64-bit versions of Windows.
Also the game must be ran as administrator for 32-bit versions of Windows Vista and newer.